On February 8, 2022, Science published online the latest results of "Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody" jointly researched by Eric Xu and Yin Wanchao of the Shanghai Institute of Pharmaceutical Research, Chinese Academy of Sciences and their partners. This study analyzed the spike protein of COVID-19 Omicron mutant, and the high-resolution freeze electron microscope structure of its receptor ACE2 and the broad-spectrum anti COVID-19 antibody JMB2002, respectively, explained the molecular mechanism of the rapid transmission and immune escape of the Omicron mutant, and revealed a new mechanism of action of the therapeutic antibody JMB2002, providing a new idea for the design and development of broad-spectrum anti COVID-19 antibody.
